In 1824 the Haig distillery was opened. In 1826 it became the first distillery to produce Grain whisky using the Column still method invented by Robert Stein. In 1877 John Haig & Co merged with 5 other whisky companies to form the Distillers Company, with John Haig & Co coming under DCL's full ownership in 1919. Cameron Bridge produced both grain and malt whisky using a combination of pot stills and column stills until 1929, when it shifted exclusively to grain whisky production.
For a period between 1941 to 1947, the distillery closed due to World War II. The current Column still house was constructed during the 1960s, and two of its three stills are more than 30 years old. The third was transferred from Carsebridge distillery in Alloa when it was closed by United Distillers in 1983. Major renovations at Cameron Bridge occurred in 1989-1992 as well as up to 2000 when the distillery produced up to 30 million imperial gallons (140,000,000 L) of spirit annually.
In 1989 Cameronbridge also changed from being solely a large-scale grain whisky distillery into a ‘dual-purpose’ site, when United Distillers’ Grain Neutral Spirit operation was transferred to Fife from Wandsworth in London. Now GNS for white spirits and ‘sweetened products’ such as Archers, Pimm's, Smirnoff, Tanqueray and Gordon's Gin are also produced alongside grain spirit used in the Johnnie Walker, J&B, Bell's, Black & White, Vat 69, Haig and White Horse blended whisky brands owned by Diageo.
It is currently the largest of the remaining grain distilleries in Scotland and is owned by Diageo.